abstract：:A 20-year-old woman presented with tendon and tuberous xanthomas. Plasma lipid levels were normal. Xanthomatosis with normal lipid levels is rare. ...

journal_title：Postgraduate medical journal

authors： Handa R,Gupta K,Wali JP

更新日期：1995-09-01 00:00:00

abstract：:Splenic peliosis was identified at necropsy in a 62-year-old woman receiving continuous ambulatory peritoneal dialysis for end-stage renal failure, and erythropoietin therapy for uraemia and anaemia. The immediate cause of death was arrhythmia related to ischaemic heart disease, following an episode of intramuscular h...

journal_title：Postgraduate medical journal

authors： Lam KY,Chan AC,Chan TM

更新日期：1995-08-01 00:00:00

abstract：:The use of self-expanding metal stents can markedly improve the care of patients with inoperable oesophageal malignancy. The stents can be easily introduced without the need for general anaesthesia. They have fewer complications during insertion than rigid stents and fewer complications than laser therapy. With these ...

journal_title：Postgraduate medical journal

authors： Murphy GJ

更新日期：1995-08-01 00:00:00

abstract：:A 19-year-old girl developed generalised anhidrosis following typhoid fever. Elaborate investigations disclosed nothing abnormal. A skin biopsy revealed the presence of atrophic as well as normal eccrine glands. This appears to be the third case of its kind in the English literature. It is postulated that typhoid feve...

journal_title：Postgraduate medical journal

authors： Raveenthiran V

更新日期：1995-07-01 00:00:00

abstract：:It has long been recognised that intensive efforts are needed to reform medical education in order to meet the future needs of populations worldwide. Pressure for changes to the organisation, content and delivery of both undergraduate and postgraduate medical education has greatly increased in the last two decades. Th...

journal_title：Postgraduate medical journal

authors： Parsell GJ,Bligh J

更新日期：1995-07-01 00:00:00

abstract：:Churg-Strauss syndrome is a systemic vasculitis. Its most frequent complications are heart diseases and asthma. Usually, cardiological manifestations are pericarditis, cardiac failure and myocardial infarction. Endobronchial granulomas identified by bronchoscopy are unusual. We present the case of a man with congestiv...

journal_title：Postgraduate medical journal

authors： Alvarez-Sala R,Prados C,Armada E,Del Arco A,Villamor J

更新日期：1995-06-01 00:00:00

abstract：:A patient with carcinoma of the stomach invading multiple adjacent organs and fungating through the anterior abdominal wall was treated by en bloc multiple organ resection and abdominal wall reconstruction. The patient is alive and well at the time of writing, six months after the operation. The rationale for embarkin...

journal_title：Postgraduate medical journal

authors： Chu KM,Lai DT,Stern HS,Sheldon DM

更新日期：1995-05-01 00:00:00

abstract：:The 1994 NACT Wyeth-Ayerst Travelling Fellowship provided the opportunity to compare the education and welfare of pre-registration house officers in the UK with their nearest counterpart in the US residency system. Investment in all aspects of learning was impressive, as was the retention of the central role of the pa...

journal_title：Postgraduate medical journal

authors： Salter R

更新日期：1995-05-01 00:00:00

abstract：:The prognosis of patients with metastatic adrenal cortical carcinoma is poor, and their disabling symptoms are usually unresponsive to conventional therapy. A patient with Cushing's syndrome secondary to a secretory adrenal cortical carcinoma was treated with octreotide, endocrine therapy and chemotherapy having faile...

journal_title：Postgraduate medical journal

authors： Pandha HS,Harrington K,Saini S,Lynn J,Peters M,Waxman J

更新日期：1995-04-01 00:00:00

abstract：:We describe two patients with associations of hereditary neuropathies and heritable skeletal disorders not previously reported. The first patient had Marfan's syndrome and hereditary motor and sensory neuropathy Type 1. The second patient had Ehlers-Danlos syndrome, Klippel-Feil syndrome and tomaculous neuropathy. ...

journal_title：Postgraduate medical journal

authors： Chattopadhyay AK,Kandler RH,Sharrack B

更新日期：1995-04-01 00:00:00

abstract：:The elderly, the very young, and the sick are known to be adversely affected by high environmental temperatures. In a retrospective open case-note review of 872 patients in a large institution during a hot summer we identified characteristics in the elderly that increase the risk of marginal hyperthermia. Women were m...

journal_title：Postgraduate medical journal

authors： Vassallo M,Gera KN,Allen S

更新日期：1995-04-01 00:00:00

abstract：:Three patients with Crohn's disease are described who were treated by ileal resection for intestinal obstruction. Histological examination of the resected specimen in each case established the diagnosis of adenocarcinoma of the small intestine complicating Crohn's disease. This diagnosis should be considered in patien...

journal_title：Postgraduate medical journal

authors： Gillen CD,Wilson CA,Walmsley RS,Sanders DS,O'Dwyer ST,Allan RN

更新日期：1995-03-01 00:00:00

abstract：:In this study we have examined the ability of senior house officers in the Accident and Emergency (A&E) Department to interpret electrocardiographs (ECGs) and tested the value of a single seminar and guidelines on interpretation. We prospectively audited ECG interpretation taken from notes over a two-month period and ...

journal_title：Postgraduate medical journal

authors： White T,Woodmansey P,Ferguson DG,Channer KS

更新日期：1995-03-01 00:00:00

abstract：:The reported impact of human monoclonal IgM antibody (HA1A) on the mortality rate from Gram-negative bacteraemia aroused considerable interest in its use in Glasgow Royal Infirmary. However, the commercial preparation of HA1A was extremely expensive. With this in mind, the Infirmary's Drugs and Therapeutics Committee ...

journal_title：Postgraduate medical journal

authors： Bell E,McCartney C

更新日期：1995-02-01 00:00:00

abstract：:Ketonaemia is well documented as a consequence of prolonged starvation, acute alcoholism, and uncontrolled diabetes mellitus. However, its occurrence in acute pancreatitis has not been described. In this report, three patients who manifested ketoacidosis at the time of presentation of acute pancreatitis are described....

journal_title：Postgraduate medical journal

authors： Kabadi UM

更新日期：1995-01-01 00:00:00

abstract：:Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII/von Willebrand factor concentrates or with the administration of desmopressin. We report a case ...

journal_title：Postgraduate medical journal

authors： Van Genderen PJ,Papatsonis DN,Michiels JJ,Wielenga JJ,Stibbe J,Huikeshoven FJ

更新日期：1994-12-01 00:00:00

abstract：:An 84 year old woman who was a heavy smoker presented with clinical features suggestive of acute exacerbation of chronic obstructive lung disease complicated by left ventricular failure. She responded poorly to treatment and then the finding of stridor, only when she was in the supine position, led to the diagnosis of...

journal_title：Postgraduate medical journal

authors： Antonios TF,Singer DR,Millard FJ,Wilson AG,MacGregor GA

更新日期：1994-12-01 00:00:00

abstract：:A 5 year old female child presented with a psoas haematoma as the first manifestation of haemophilia B. Molecular genetic studies were performed to investigate the inheritance of the disorder and the mechanisms by which females may express the haemophilia B phenotype are discussed. ...

journal_title：Postgraduate medical journal

authors： Palmer S,Standen GR,Yates P,Oakhill A

更新日期：1994-11-01 00:00:00

abstract：:We report a 71 year old lady who presented with weight loss, rectal bleeding and bilateral foot drop having been previously fit and well. Clinical examination, laboratory investigation and postmortem examination confirmed the diagnosis of active Crohn's disease and acute peripheral neuropathy. The clinical course of t...

journal_title：Postgraduate medical journal

authors： Gariballa SE,Gunasekera NP

更新日期：1994-10-01 00:00:00

abstract：:This paper reports a clinical study of 20 cases of gangrenous ulcers of the scrotum and/or of the penis (Fournier's gangrene) and a review of previous publications. Even though found mostly in elderly male patients, the disease spares no age group and can involve the external genitalia in neonates and women as well. T...

journal_title：Postgraduate medical journal

authors： Efem SE

更新日期：1994-08-01 00:00:00

abstract：:A case of ovarian carcinoma and systemic amyloidosis in a 64 year old woman with nephrotic syndrome is reported. Immunohistochemical study of renal and rectal biopsy specimens revealed the presence of amyloidosis AA antigens, consistent with secondary amyloidosis. The absence of chronic inflammatory or infectious dise...

journal_title：Postgraduate medical journal

authors： Fernandez-Miranda C,Mateo S,Gonzalez-Gomez C,Ballestin C

更新日期：1994-07-01 00:00:00

abstract：:Thrombolysis has been very effective in reducing the morbidity and mortality from acute myocardial infarction. Serious adverse events are not uncommon, however. We describe a case in which a haemopericardium and tamponade developed in a patient with a history of recurrent idiopathic pericarditis and to whom streptokin...

journal_title：Postgraduate medical journal

authors： Heymann TD,Culling W

更新日期：1994-06-01 00:00:00

abstract：:A 46 year old woman presented with the CREST variety of systemic sclerosis and occult gastrointestinal bleeding due to vascular malformations of her stomach. Partial gastrectomy cured her anaemia. In systemic sclerosis, visceral angiography should be performed early when initial investigations have been negative. ...

journal_title：Postgraduate medical journal

authors： el-Omar MM,Jenkins AP,Hollowood K,Banerjee AK,Thompson RP

更新日期：1994-04-01 00:00:00

abstract：:Ruptured abdominal aortic aneurysm currently accounts for about 1 in 200 deaths and is a critical surgical emergency with an average hospital mortality of 50%. The combination of acute massive haemorrhage in an elderly patient with pre-existing medical disease is highly lethal and a major challenge for any health care...

journal_title：Postgraduate medical journal

authors： Brimacombe J,Berry A

更新日期：1994-04-01 00:00:00

abstract：:We report the case of a 66 year old woman with clinical manifestations of giant-cell arteritis, positive temporal artery biopsy and excellent response to prednisone, who developed massive cerebral infarcts after 5 days of treatment. Computed tomographic and magnetic resonance imaging scans revealed multiple infarcts i...

journal_title：Postgraduate medical journal

authors： Collazos J,García-Moncó C,Martín A,Rodriguez J,Gómez MA

更新日期：1994-03-01 00:00:00

abstract：:To determine the prevalence and extent of autonomic neuropathy amongst Africans with insulin-dependent diabetes mellitus (IDDM), we investigated 50 such patients at our clinic. Mean age (+/- 1 s.d.) was 26 +/- 6 years, male:female ratio was equal (25M:25F) and duration of diabetes was 4.0 +/- 3.0 years. A battery of s...

journal_title：Postgraduate medical journal

authors： Tuch PS,Gill GV,Huddle KR

更新日期：1994-03-01 00:00:00

abstract：:This is a case report of a boy who presented with unilateral foot drop approximately 1 year after traumatic injury from skateboarding. Exploratory surgical operation was eventually performed, and histological examination of the surgical specimen revealed leprous peripheral neuropathy of the peroneal nerve. The patient...

journal_title：Postgraduate medical journal

authors： Choe W

更新日期：1994-02-01 00:00:00

abstract：:Proper understanding of the pathological process of a ruptured plaque followed by thrombus formation remains the basis for rational therapy of cardiac ischaemia and myocardial infarction. With the advent of better thrombolytic regimens, improved direct reperfusion via angioplasty and streamlined recognition/admission ...

journal_title：Postgraduate medical journal

authors： Hugenholtz PG

更新日期：1994-01-01 00:00:00

abstract：:Rhabdomyolysis is a rare but potentially fatal complication of hyperosmolar states. We report a case of severe hyperosmolar non-ketotic diabetic coma causing rhabdomyolysis in a young man. Despite very high levels of creatine kinase there was no detectable myoglobinuria. Creatine kinase estimation should be a standard...

journal_title：Postgraduate medical journal

authors： Trump D,O'Hanlon S,Rinsler M,Sharp P

更新日期：1994-01-01 00:00:00

abstract：:Clinical, endocrinological and computed tomographic features of three patients with unusual manifestations or complications of craniofacial involvement of fibrous dysplasia are presented. One patient with polyostotic fibrous dysplasia presented in late pregnancy with acute onset of bilateral optic nerve compression an...

journal_title：Postgraduate medical journal

authors： Daly BD,Chow CC,Cockram CS

更新日期：1994-01-01 00:00:00

abstract：:A 65 year old man was admitted with segmental consolidation of the left upper lobe after having stayed in a hotel for 2 days. He deteriorated rapidly on conventional antibiotic therapy and required ventilatory support. Acinetobacter calcoaceticus var. anitratus was grown from the sputum and blood cultures, which was t...

journal_title：Postgraduate medical journal

authors： Achar KN,Johny M,Achar MN,Menon NK

更新日期：1993-12-01 00:00:00

abstract：:Spironolactone therapy is a well-known cause of hyperkalaemia, but in susceptible patient, it may also be associated with metabolic acidosis. We report a case of severe renal tubular acidosis (Type IV) with life-threatening hyperkalaemia caused by spironolactone, and discuss the mechanisms by which this may occur. ...

journal_title：Postgraduate medical journal

authors： O'Connell JE,Colledge NR

更新日期：1993-11-01 00:00:00

abstract：:We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1-11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multip...

journal_title：Postgraduate medical journal

authors： Briedigkeit L,Kettritz R,Göbel U,Natusch R

更新日期：1993-11-01 00:00:00

abstract：:Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-C...

journal_title：Postgraduate medical journal

authors： Kendra JR,Rugman FP,Flaherty TA,Myers A,Horsfield N,Barton A,Russell L

更新日期：1993-11-01 00:00:00

abstract：:Fistulous communications of the uterus are relatively unknown. We report in this paper the first case to our knowledge of uterocutaneous fistula which developed following a septic abortion induced by introduction of Laminaria tent into the uterus. ...

journal_title：Postgraduate medical journal

authors： Gupta SK,Shukla VK,Varma DN,Roy SK

更新日期：1993-10-01 00:00:00

abstract：:We report four cases of Bartter's syndrome in two consecutive generations of an Irish family. Diagnoses were made on the basis of characteristic clinical features, blood and urine biochemistry with additional evidence from renal biopsy in one case. The aetiology, treatment and inheritance of the syndrome are discussed...

journal_title：Postgraduate medical journal

authors： Crowe P,Ahmad A,O'Byrne K,Cullen MJ

更新日期：1993-10-01 00:00:00

abstract：:Ganglioneuroblastoma in the spinal region is rare, the treatment of choice being surgical excision. We present a 21 year old male who was diagnosed to have this condition in the dorsolumbar spinal region. The tumour was extending intraspinally and was unresectable. Combination chemotherapy with Adriamycin (doxorubicin...

journal_title：Postgraduate medical journal

authors： Raina V,Kamble R,Tanwar R,Singh SP,Sharma S

更新日期：1993-09-01 00:00:00

abstract：:A fatal case of occult foramen magnum meningioma is described which presented with features of cervical myelopathy confirmed by cervical myelogram. Surgical decompression led to initial improvement followed by progressive deterioration and death. Postmortem examination revealed a 4 cm diameter foramen magnum meningiom...

journal_title：Postgraduate medical journal

authors： Chakravarty K,Scott DG,Dick D,Visick J

更新日期：1993-09-01 00:00:00

abstract：:A young man who presented with a 3 week history of fever and severe headache accompanied by mild leukocytosis, was found to have lymphocytic meningitis due to Coxiella burnetti. Thus, Q fever can present as lymphocytic (aseptic) meningitis responsive to tetracycline with no evidence of pulmonary involvement. ...

journal_title：Postgraduate medical journal

authors： Schattner A,Kushnir M,Zhornicky T,Fenakel G

更新日期：1993-08-01 00:00:00

abstract：:A patient with disseminated ovarian carcinoma presented with symptoms of hypocalcaemia secondary to hypomagnesaemia. The low serum magnesium (0.4 mmol/l) appeared to be due to renal leakage with no evidence of ureteric obstruction or hydronephrosis on intravenous urogram. Parathyroid hormone activity (serum levels and...

journal_title：Postgraduate medical journal

authors： Leese GP,Jung RT,Browning MC

更新日期：1993-07-01 00:00:00